Efficacy and safety of oxandrolone in growth hormone-treated girls with turner syndrome


Context and Objective: GH therapy increases growth and adult height in Turner syndrome (TS). The benefit to risk ratio of adding the weak androgen oxandrolone (Ox) to GH is unclear. Design and Participants: A randomized, placebo-controlled, double-blind, dose-response study was performed in 10 centers in The Netherlands. One hundred thirty-three patients with TS were included in age group 1 (2-7.99 yr), 2 (8-11.99 yr), or 3 (12-15.99 yr). Patients were treated with GH (1.33 mg/m(2). d) from baseline, combined with placebo (Pl) or Ox in low (0.03 mg/kg. d) or conventional (0.06 mg/kg. d) dose from the age of 8 yr and estrogens from the age of 12 yr. Adult height gain (adult height minus predicted adult height) and safety parameters were systematically assessed. Results: Compared with GH+Pl, GH+Ox 0.03 increased adult height gain in the intention-to-treat analysis (mean +/- sd, 9.5 +/- 4.7 vs. 7.2 +/- 4.0 cm, P = 0.02) and per-protocol analysis (9.8 +/- 4.9 vs. 6.8 +/- 4.4 cm, P = 0.02). Partly due to accelerated bone maturation (P < 0.001), adult height gain on GH+Ox 0.06 was not significantly different from that on GH+Pl (8.3 +/- 4.7 vs. 7.2 +/- 4.0 cm, P = 0.3). Breast development was slower on GH+Ox (GH+Ox 0.03, P = 0.02; GH+Ox 0.06, P = 0.05), and more girls reported virilization on GH+Ox 0.06 than on GH+Pl (P < 0.001). Conclusions: In GH-treated girls with TS, we discourage the use of the conventional Ox dosage (0.06 mg/kg. d) because of its low benefit to risk ratio. The addition of Ox 0.03 mg/kg. d modestly increases adult height gain and has a fairly good safety profile, except for some deceleration of breast development. JID: 0375362; 0 (Androgens); 0 (Recombinant Proteins); 12629-01-5 (Human Growth Hormone); 53-39-4 (Oxandrolone); 2010/01/08 [aheadofprint]; ppublish

J. Clin. Endocrinol. Metab.
Stef van Buuren
Stef van Buuren

My research interests include data science, missing data, child growth and development, and measurement.