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Broken stick model for irregular longitudinal data

Many longitudinal studies collect data that have irregular observation times, often requiring the application of linear mixed models with time-varying outcomes. This paper presents an alternative that splits the quantitative analysis into two steps. …

Artifacts annotations in anesthesia blood pressure data by man and machine

Physiologic data from anesthesia monitors are automatically captured. Yet erroneous data are stored in the process as well. While this is not interfering with clinical care, research can be affected. Researchers should find ways to remove artifacts. …

Reference chart for knee flexion following total knee arthroplasty: A novel tool for monitoring postoperative recovery.

**BACKGROUND**: Clinicians and patients lack an evidence-based framework by which to judge individual-level recovery following total knee arthroplasty (TKA) surgery, thus impeding personalized treatment approaches for this elective surgery. Our study …

Artifact processing methods influence on intraoperative hypotension quantification and outcome effect estimates

**Background**: Physiologic data that is automatically collected during anesthesia is widely used for medical record keeping and clinical research. These data contain artifacts, which are not relevant in clinical care, but may influence research …

Patient and anesthesia characteristics of children with low pre‐incision blood pressure: A retrospective observational study

**Background**: Intraoperative blood pressure has been suggested as a key factor for safe pediatric anesthesia. However, there is not much insight into factors that discriminate between children with low and normal pre‐incision blood pressure. Our …

The D-score: A metric for interpreting the early development of infants and toddlers across global settings

**Introduction**: Early childhood development can be described by an underlying latent construct. Global comparisons of children’s development are hindered by the lack of a validated metric that is comparable across cultures and contexts, especially …

The Global Scale for Early Development (GSED)

Countries need good metrics to track their progress towards early childhood development targets. No reliable, freely accessible tools exist for population-level monitoring of children up to age 3. The Global Scale for Early Development, now being …

Multiple imputation in data that grow over time: A comparison of three strategies

Multiple imputation is a highly recommended technique to deal with missing data, but the application to longitudinal datasets can be done in multiple ways. When a new wave of longitudinal data arrives, we can treat the combined data of multiple waves …

Graphical uncertainty representations for ensemble predictions

We investigated how different graphical representations convey the underlying uncertainty distribution in ensemble predictions. In ensemble predictions, a set of forecasts is produced, indicating the range of possible future states. Adopting a use …

Combining multiple imputation and bootstrap in the analysis of cost-effectiveness trial data

In healthcare cost-effectiveness analysis, probability distributions are typically skewed and missing data are frequent. Bootstrap and multiple imputation are well-established resampling methods for handling skewed and missing data. However, it is …